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14-660M Itk Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617. For use in Kinase Assays.

Itk Protein, active, 250 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-660M
250 µg  Also available in 10 μg size (cat#14-660) and in bulk (cat# 14-660-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-660M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionItk Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceHuman Itk expressed by baculovirus in Sf21 cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
      Gene Symbol
      • ITK
      • LYK
      • PSCTK2
      • EMT
      • MGC126258
      • MGC126257
      Protein TargetItk
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q08881 # Plays a role in T-cell proliferation and differentiation.
      COFACTOR: Binds 1 zinc ion per subunit (By similarity).
      SIZE: 620 amino acids; 71831 Da
      SUBCELLULAR LOCATION: Cell membrane (By similarity). Note=Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T- cells (By similarity).
      TISSUE SPECIFICITY: T-cell lines and natural killer cell lines.
      SIMILARITY: SwissProt: Q08881 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight34kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of MBP.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-660) and in bulk (cat# 14-660-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-660M 04053252743894

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-660 Itk Protein, active, 10 µg Show Pricing & Availability

      Product Families

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      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases