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407601 Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS 509093-47-4, is a cell-permeable, potent and selective inhibitor of IRAK-1 (IC50 = 300 nM) and IRAK-4 (IC50 = 200 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor

Primary Target: Interleukin-1 receptor-associated kinases
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407601
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Overview

Key Spec Table

CAS #Empirical Formula
509093-47-4C₂₀H₂₁N₅O₄

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407601-5MG
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      Description
      OverviewA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).
      Catalogue Number407601
      Brand Family Calbiochem®
      SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, IRAK-1/4 Inhibitor
      References
      ReferencesBhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
      Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
      Product Information
      CAS number509093-47-4
      ATP CompetitiveN
      FormYellow crystalline solid
      Hill FormulaC₂₀H₂₁N₅O₄
      Chemical formulaC₂₀H₂₁N₅O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInterleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, CAS 509093-47-4, is a cell-permeable, potent and selective inhibitor of IRAK-1 (IC50 = 300 nM) and IRAK-4 (IC50 = 200 nM).
      Biological Information
      Primary TargetInterleukin-1 receptor-associated kinases
      Primary Target IC<sub>50</sub>300 nM and 200 nM for IRAK-1 and -4
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      407601-5MG 04055977211290