Millipore Sigma Vibrant Logo

407271 Integrin αMβ₂ Ligand - CAS 307525-40-2 - Calbiochem

View Products on Sigmaaldrich.com
407271
  
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Fulfillment and Delivery Delayed
Fulfillment and Delivery Delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

       

      Contact Customer Service

      Overview

      Key Spec Table

      CAS #Empirical Formula
      307525-40-2C₁₉H₁₅NOS₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable thioxothiazolidine compound that displays anti-inflammatory properties. Shown to increase cell adhesion and lowers leukemia cell migration in vitro and leukocyte recruitment in vivo and displays anti-inflammatory properties. Binds to and stabilizes integrin αM I domain active conformation and enhances the ligands' (pro-MMP-9 and fibrinogen) binding ability.

      Catalogue Number407271
      Brand Family Calbiochem®
      Synonyms3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I
      References
      ReferencesBjorklund, M., et al. 2006. Biochemistry 45, 2862.
      Product Information
      CAS number307525-40-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₅NOS₂
      Chemical formulaC₁₉H₁₅NOS₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetBinds to and stabilizes integrin αM I domain active conformation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      407271 0