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407271 Integrin αMβ₂ Ligand - CAS 307525-40-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I

Primary Target: Binds to and stabilizes integrin αM I domain active conformation
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      307525-40-2C₁₉H₁₅NOS₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable thioxothiazolidine compound that displays anti-inflammatory properties. Shown to increase cell adhesion and lowers leukemia cell migration in vitro and leukocyte recruitment in vivo and displays anti-inflammatory properties. Binds to and stabilizes integrin αM I domain active conformation and enhances the ligands' (pro-MMP-9 and fibrinogen) binding ability.
      Catalogue Number407271
      Brand Family Calbiochem®
      Synonyms3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, αMβ2 Agonist I, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I
      References
      ReferencesBjorklund, M., et al. 2006. Biochemistry 45, 2862.
      Product Information
      CAS number307525-40-2
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₅NOS₂
      Chemical formulaC₁₉H₁₅NOS₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetBinds to and stabilizes integrin αM I domain active conformation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      407271 0