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584223 InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
18771-50-1C₉H₁₆N₂O₆ • 2H₂O

Pricing & Availability

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584223-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
      Catalogue Number584223
      Brand Family Calbiochem®
      Synonyms1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate, THU, H4U
      References
      ReferencesYusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
      Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
      Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
      Riva, C., et al. 1992. Chemotherapy 38, 358.
      Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
      Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.
      Product Information
      CAS number18771-50-1
      FormLiquid
      FormulationA 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
      Hill FormulaC₉H₁₆N₂O₆ • 2H₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetcytidine deaminase
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      584223-25MG 04055977264999