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504744 InSolution™ Aphidicolin - CAS 38966-21-1 - Calbiochem

A 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: DNA polymerase α and δ
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504744
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
38966-21-1C₂₀H₃₄O₄

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      		 Glass bottle 1 mg
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      Description
      Catalogue Number504744
      Brand Family Calbiochem®
      References
      ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
      Poluha, W., et al. 1995. Oncogene 10, 185.
      Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.
      Product Information
      CAS number38966-21-1
      FormLiquid
      FormulationA 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.
      Hill FormulaC₂₀H₃₄O₄
      Chemical formulaC₂₀H₃₄O₄
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA polymerase α and δ
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 24/25

      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.04744.0001 04055977244076

      Documentation

      InSolution™ Aphidicolin - CAS 38966-21-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Borner, M.M., et al. 1995. Cancer Res. 55, 2122.
      Poluha, W., et al. 1995. Oncogene 10, 185.
      Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-January-2014 JSW
      DescriptionA cell-permeable tetracyclic diterpene antibiotic. Cell synchronization agent. Blocks the cell cycle at the early S-phase. Specific, non-competitive and reversible inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLaS3 cells, but inhibits vincristine (Cat. No. 677181)-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
      FormLiquid
      FormulationA 30 mM (1 mg/98 µL) sterile-filtered solution of Aphidicolin (Cat. No. 178273) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number38966-21-1
      Chemical formulaC₂₀H₃₄O₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions.
      Toxicity Irritant
      ReferencesBorner, M.M., et al. 1995. Cancer Res. 55, 2122.
      Poluha, W., et al. 1995. Oncogene 10, 185.
      Urbani, L., et al. 1995. Exp. Cell Res. 219, 159. Schimke, R.T., et al. 1994. Philos. Trans. R. Soc. London. B. Biol. Sci. 345, 311. Kuwakado, K., et al. 1993. Biochem. Pharmacol. 46, 1909. Hubermann, J.A. 1981. Cell 23, 647.