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407248 IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem

The IGF-1R Inhibitor II, also referenced under CAS 196868-63-0, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401

Primary Target: IGF-1R
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      196868-63-0C₁₈H₁₆ClN₃O₂
      Description
      OverviewA cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC50 = 12 µM in inhibiting ligand-induced autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay). Reduces IGF-1R-dependent tumor cell growth both in vitro (IC50 = 8 and 15 µM for MCF-7 and MCNeuA, respectively) and in mice in vivo (80% reduction, 100 mg/kg thrice a week, i.p.). The mechanism of inhibition probably involves indirect blocking of ATP binding.
      Catalogue Number407248
      Brand Family Calbiochem®
      SynonymsN-(2-Methoxy-5-chlorophenyl)-Nʹ-(2-methylquinolin-4-yl)-urea, PQ401
      References
      ReferencesGable, K.L., et al. 2006. Mol. Cancer Ther. 5, 1079.
      Product Information
      CAS number196868-63-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₈H₁₆ClN₃O₂
      Chemical formulaC₁₈H₁₆ClN₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetIGF-1R
      Primary Target IC<sub>50</sub>12 µM in inhibiting ligand-induced IGF-1R autophosphorylation in MCF-7 cells and < 1 µM in a cell-free kinase assay; 8 and 15 µM in reducing IGF-1R-dependent tumor cell growth both in vitro for MCF-7 and MCNeuA, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      407248 0