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538256 IDO Inhibitor - CAS 914471-09-3 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
914471-09-3C₉H₇ClFN₅O₂

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, bioactive, non-toxic oxadiazolohydroxyamidine based compound that acts as a potent, selective and competitive inhibitor of indoleamine 2,3-dioxygenase (IDO; IC50 = 67 nM for hIDO). Reversibly binds to the catalytically active heme iron (Fe2+) and is inactive towards closely related tryptophan 2,3-dioxygenase (TDO; IC50 > 10 µM). Shown to dose-dependently decrease kynurenine levels (IC50 = 19 & 46 nM in HeLa treated with IFN-γ & B16-GM-CSF melanoma cells, respectively) and suppress B16-GM-CSF xenograft tumor growth in C57BL/6 mice (75 mg/kg, s.c., b.i.d.). Though orally bioavailable, but undergoes a rapid clearance (t1/2 < 0.5 h).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number538256
      Brand Family Calbiochem®
      Synonyms4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor
      DescriptionIDO Inhibitor
      References
      ReferencesYue, E.W., et al. 2009. J. Med. Chem. 52, 7364.
      Product Information
      CAS number914471-09-3
      FormOff-white powder
      Hill FormulaC₉H₇ClFN₅O₂
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetIDO
      Primary Target IC<sub>50</sub>67 nM for hIDO
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.38256.0001 04054839059513