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420351 ICMT Inhibitor II, FTPAT - CAS 1350561-58-8 - Calbiochem

The ICMT Inhibitor II, FTPAT controls the biological activity of ICMT.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-methyl-3-((5-(4-(2-((1,1ʹ-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

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420351
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1350561-58-8C₂₆H₃₁N₃O₂S

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420351-10MG
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      Description
      OverviewA cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT; IC50 = 800 nM; Ki = 400 nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50 = 33 and >100 µM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50 = 8 µM).
      Catalogue Number420351
      Brand Family Calbiochem®
      Synonyms(E)-methyl-3-((5-(4-(2-((1,1ʹ-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate
      References
      ReferencesBergman, J.A., et al. 2012. ACS Med. Chem. Lett. 3, 15.
      Product Information
      CAS number1350561-58-8
      FormWhite solid
      Hill FormulaC₂₆H₃₁N₃O₂S
      Chemical formulaC₂₆H₃₁N₃O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      420351-10MG 04055977187526

      Documentation

      ICMT Inhibitor II, FTPAT - CAS 1350561-58-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      ICMT Inhibitor II, FTPAT - CAS 1350561-58-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      420351

      References

      Reference overview
      Bergman, J.A., et al. 2012. ACS Med. Chem. Lett. 3, 15.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      Synonyms(E)-methyl-3-((5-(4-(2-((1,1ʹ-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate
      DescriptionA cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT; IC50 = 800 nM; Ki = 400 nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50 = 33 and >100 µM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50 = 8 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1350561-58-8
      Chemical formulaC₂₆H₃₁N₃O₂S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBergman, J.A., et al. 2012. ACS Med. Chem. Lett. 3, 15.