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382172 Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem

The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-Hydroxy-7-(2-naphthylthio)heptanomide

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382172
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
926908-04-5C₁₇H₂₁NO₂S

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382172-10MG
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      Description
      OverviewA cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
      Catalogue Number382172
      Brand Family Calbiochem®
      SynonymsN-Hydroxy-7-(2-naphthylthio)heptanomide
      References
      ReferencesKim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.
      Product Information
      CAS number926908-04-5
      FormWhite solid
      Hill FormulaC₁₇H₂₁NO₂S
      Chemical formulaC₁₇H₂₁NO₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      382172-10MG 04055977212785

      Documentation

      Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      382172

      References

      Reference overview
      Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsN-Hydroxy-7-(2-naphthylthio)heptanomide
      DescriptionA cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number926908-04-5
      Chemical formulaC₁₇H₂₁NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesKim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.