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AG217 Histamine Receptor 4, control peptide for AB5663P

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Research Category: Signaling Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: HRH4, MGC133027, GPCR105, HH4R, GPRv53, H4R, H4, AXOR35, SP9144, BG26 UniProt Number: Q9H3N8
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AG217
100 µg  
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      Description
      Catalogue NumberAG217
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionHistamine Receptor 4, control peptide for AB5663P
      OverviewSynthetic 17 amino acid peptide sequence within the cytoplasmic, C-terminus of human HR4.
      References
      Product Information
      PresentationLiquid in PBS containing 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      Key Applications
      • Cell Function Assay
      Application NotesFor use in blocking the reactivity of AB5663P.

      Optimal working dilution must be determined by the end user.
      Biological Information
      Concentration1.0 mg/mL
      Entrez Gene Number
      Entrez Gene SummaryHistamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.
      Gene Symbol
      • HRH4
      • MGC133027
      • GPCR105
      • HH4R
      • GPRv53
      • H4R
      • H4
      • AXOR35
      • SP9144
      • BG26
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9H3N8 # The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
      SIZE: 390 amino acids; 44496 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, fetal liver and lymph node.
      SIMILARITY: SwissProt: Q9H3N8 ## Belongs to the G-protein coupled receptor 1 family.
      MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- methylhistamine > R(-)-alpha-methylhistamine behave as full agonists.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AG217 04053252286759