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373225 Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V

Primary Target: ubiquitination of p53 in vitro
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373225
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
414905-09-2C₁₀H₈F₆N₂O₃S

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373225-5MG
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      Description
      Overview

      This product has been discontinued.



      A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 > 100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
      Catalogue Number373225
      Brand Family Calbiochem®
      SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
      References
      ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
      Product Information
      CAS number414905-09-2
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₀H₈F₆N₂O₃S
      Chemical formulaC₁₀H₈F₆N₂O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetubiquitination of p53 in vitro
      Primary Target IC<sub>50</sub>12.7 µM inhibiting ubiquitination of p53 in vitro using Ub-Ubc as the donor substrate
      Purity≥95% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      373225-5MG 04055977190977

      Documentation

      Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      373225

      References

      Reference overview
      Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-July-2014 JSW
      SynonymsN-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
      DescriptionA cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 >100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number414905-09-2
      Chemical formulaC₁₀H₈F₆N₂O₃S
      Structure formulaStructure formula
      Purity≥95% by NMR
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14734.