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373210 HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem

The HDL Receptor SR-BI Inhibitor, BLT-1, also referenced under CAS 321673-30-7, controls the biological activity of HDL Receptor SR-B. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Block Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20

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373210
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
321673-30-7C₁₂H₂₃N₃S

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373210-25MG
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      Description
      OverviewA cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
      Catalogue Number373210
      Brand Family Calbiochem®
      SynonymsBlock Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
      References
      ReferencesNieland, T.J.F., et al. 2008. Biochemistry 47, 460.
      Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
      Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
      Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.
      Product Information
      CAS number321673-30-7
      FormWhite solid
      Hill FormulaC₁₂H₂₃N₃S
      Chemical formulaC₁₂H₂₃N₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      373210-25MG 04055977191608

      Documentation

      HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      HDL Receptor SR-BI Inhibitor, BLT-1 - CAS 321673-30-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      373210

      References

      Reference overview
      Nieland, T.J.F., et al. 2008. Biochemistry 47, 460.
      Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
      Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
      Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsBlock Lipid Transport-1, 2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20
      DescriptionA cell-permeable thiosemicarbazone copper chelator that potently blocks the HDL receptor SR-BI- (scavenger receptor, class B, type I) mediated lipid uptake (IC50 = 21 and 57 nM against DiI and CE uptake, respectively, from DiI-HDL and CE-HDL using hamster ldlA-7 cells expressing murine SR-BI) in a reversible manner, while exerting little effect toward intracellular membrane trafficking or cytoskeletal organization. BLT-1 chelates Cu+2 in a 2:1 stoichiometric ratio and a half molar equivalent of CuCl2 is shown to fully prevent zebrafish embryos from BLT-1-induced development defects, while BLT-1 can likewise be used to chelate excess amount of copper (>4 µM) and rescue embryos from copper toxicity.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number321673-30-7
      Chemical formulaC₁₂H₂₃N₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesNieland, T.J.F., et al. 2008. Biochemistry 47, 460.
      Raldua, D., and Babin, P.J. 2007. Toxicol. Lett. 175, 1.
      Nieland, T.J.F., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 15422.
      Peterson, R.T., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 12965.