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371545 Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GTPγ-S, 4Li

Primary Target: G-protein-activating GTP analog
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      94825-44-2C₁₀H₁₂N₅O₁₃P₃S . 4Li
      Description
      OverviewG-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.
      Catalogue Number371545
      Brand Family Calbiochem®
      SynonymsGTPγ-S, 4Li
      References
      ReferencesIino, S., et al. 2000. FEBS Lett. 479, 46.
      Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
      Hess, S.D., et al. 1993. Science 259, 1169.
      Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183.
      McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117.
      Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66.
      Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466.
      Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615.
      Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
      Product Information
      CAS number94825-44-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
      Chemical formulaC₁₀H₁₂N₅O₁₃P₃S . 4Li
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetG-protein-activating GTP analog
      Purity≥85% by HPLC.
      Physicochemical Information
      Cell permeableN
      ContaminantsGDP: ≤12%
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      371545 0