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368043 Granzyme B, Human, Recombinant, E. coli

Granzyme B, Human, Recombinant, E. coli, is a serine protease used by activated cytotoxic T cells to induce apoptosis. Induces cell perforation and initiates proteolysis leading to cell death.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GzmB

368043
  
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      Overview

      Description
      OverviewRecombinant, human granzyme B expressed in E. coli. Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes (CTL) to induce target cell apoptosis. It is involved in the perforation of target cells and initiation of proteolysis that leads the cell into the apoptosis pathway.
      Catalogue Number368043
      Brand Family Calbiochem®
      SynonymsGzmB
      References
      ReferencesWilharm, E., et al. 1999. J. Biol. Chem. 274, 27331.
      Harris, J. L., et al. 1998. J. Biol. Chem. 273, 27364.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1 nmol Ac-IEPD-<i>p</i>NA per min 25° C, pH 8.0.
      EC number3.4.21.79
      FormLiquid
      FormulationIn TBS, 50% glycerol.
      Applications
      ApplicationGranzyme B, Human, Recombinant, E. coli, is a serine protease used by activated cytotoxic T cells to induce apoptosis. Induces cell perforation and initiates proteolysis leading to cell death.
      Biological Information
      Specific Activity≥7.0 units/µg protein
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Global Trade Item Number
      Catalogue Number GTIN
      368043 0