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368020 Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem

Gramicidin A, High Purity, Bacillus brevis, CAS 11029-61-1, is a naturally-occurring ion channel-forming pentadecapeptide. Causes K+/H+ exchange in mitochondria in a non-voltage dependent manner.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: gA

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368020
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
11029-61-1C₉₉H₁₄₀N₂₀O₁₇

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      Description
      OverviewNaturally-occurring ion channel-forming pentadecapeptide. The association of two gA peptides causes the formation of a monovalent cation-selective ion channel. Causes K+/H+ exchange in mitochondria in a non-voltage dependent manner. Causes red blood cell lysis at 0.5-1.0 µg/ml.
      Catalogue Number368020
      Brand Family Calbiochem®
      SynonymsgA
      References
      ReferencesQuigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
      Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
      Ketchem, R.R., et al. 1993. Science 261, 1457.
      Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.
      Product Information
      CAS number11029-61-1
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₉₉H₁₄₀N₂₀O₁₇
      Chemical formulaC₉₉H₁₄₀N₂₀O₁₇
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCauses the formation of a monovalent cation-selective ion channel
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      ContaminantsgC isomers: < 5% by HPLC
      Peptide SequenceHCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH₂CH₂OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMD8230000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing recosntituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      368020-25MG 04055977192094

      Documentation

      Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      368020

      References

      Reference overview
      Quigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
      Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
      Ketchem, R.R., et al. 1993. Science 261, 1457.
      Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-March-2012 JSW
      SynonymsgA
      DescriptionNaturally occurring, ion channel-forming pentadecapeptide antibiotic that renders membranes permeable to protons and alkali metal ions. Causes red blood cell lysis at concentrations of 0.5-1.0 µg/ml. Gramicidin A causes K+/H+ exchange in mitochondria in a non-voltage dependent manner.
      FormWhite to off-white solid
      CAS number11029-61-1
      RTECSMD8230000
      Chemical formulaC₉₉H₁₄₀N₂₀O₁₇
      Peptide SequenceHCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH₂CH₂OH
      Purity≥90% by HPLC
      ContaminantsgC isomers: < 5% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing recosntituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 4532
      ReferencesQuigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
      Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
      Ketchem, R.R., et al. 1993. Science 261, 1457.
      Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.

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