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GLP1A-35HK Glucagon Like Peptide-1 (Active) RIA

This radioimmunoassay (RIA) measures & quantifies Glucagon Like Peptide-1 for use in Metabolism & Endocrine research.

Glucagon Like Peptide-1 (Active) RIA MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Radioimmunoassay Detection Methods: Radioactive, 125I Research Category: Metabolism Research Sub-Category: Obesity, Metabolic Disorders
GLP1A-35HK
125 tubes  
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      Overview

      Replacement Information

      Key Spec Table

      Analytes AvailableSpecies ReactivityKey ApplicationsDetection Methods
      Glucagon Like Peptide-1 H, M, RRIARadioactive 125I
      Description
      Catalogue NumberGLP1A-35HK
      DescriptionGlucagon Like Peptide-1 (Active) RIA
      Background InformationGLP-1 is secreted from gut endocrine cells in response to nutrient ingestion and plays multiple roles in metabolic homeostasis.
      References
      Product Information
      Detection methodRadioactive 125I
      Performance
      • ED80 = 28 ± 7 pM
      • ED50 = 82 ± 10 pM
      • ED 20 = 241 ± 24 pM
      Precision, %
      • Inter-assay: 26.7 ± 12.7
      • Intra-assay: 26.5 ± 4.7
      Quality LevelMQ100
      Applications
      ApplicationThis radioimmunoassay (RIA) measures & quantifies Glucagon Like Peptide-1 for use in Metabolism & Endocrine research.
      Key Applications
      • Radioimmunoassay
      Application NotesTwo-day disequilibrium assay at 4°C. Sample volume = 300 μL plasma (extraction required)
      Biological Information
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Analytes Available
      • Glucagon Like Peptide-1
      Cross ReactivityGLP-1 is conserved in almost all mammals. This kit may be used to measure GLP-1 in these samples (e.g. rat, mouse, etc.)
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
      Gene Symbol
      • GCG
      • GLP1
      • glucagon
      • GRPP
      • GLP2
      Radioactive Isotype125I-GLP-1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
      SIZE: 180 amino acids; 20909 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
      PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
      SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.
      MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo.
      Accuracy
      • 40.7 ± 2.9%
      Physicochemical Information
      Standard Curve Range
      • 10–500 pM
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size125 tubes
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GLP1A-35HK 04053252408922

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      Categories

      Life Science Research > Antibodies and Assays > Immunoassays > Radioimmunoassay (RIA) > Complete RIA Kits
      Life Science Research > Protein Detection and Quantification > Immunoassays > Radioimmunoassay (RIA) > Complete RIA Kits