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361540 GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
327036-89-5C₁₀H₁₀N₂SO₂

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361540-5MG
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      Description
      OverviewA thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). Binds to the active site of GSK-3β.
      Catalogue Number361540
      Brand Family Calbiochem®
      SynonymsTDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
      References
      ReferencesGuzman, M.L., et al. 2007. Blood 110, 4436.
      Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
      Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.
      Product Information
      CAS number327036-89-5
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₁₀H₁₀N₂SO₂
      Chemical formulaC₁₀H₁₀N₂SO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>2 µM, 673 nM, 1.4-5.5 µM, against GSK-3β, Flt-3, and PKC activities, respectively
      Purity≥ 95% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      361540-5MG 07790788049584