Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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508014
Sigma-AldrichGR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem
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Description
Overview
A selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.
Rex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior.88, 196. Przegalinski, E. et al. 2008. Pharmacol. Rep.60, 798. Bannai, M. et al. 2007. Psychopharmacol.93, 295. McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther.290, 965. Pauwels, P. J. et al. 1996. J. Neurochem.66, 65. Skingle, M. et al. 1996. Behav.Brain Res.73, 157.
GR 127935 Hydrochloride - CAS 148642-42-6 - Calbiochem Certificates of Analysis
Title
Lot Number
508014
References
Reference overview
Rex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior.88, 196. Przegalinski, E. et al. 2008. Pharmacol. Rep.60, 798. Bannai, M. et al. 2007. Psychopharmacol.93, 295. McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther.290, 965. Pauwels, P. J. et al. 1996. J. Neurochem.66, 65. Skingle, M. et al. 1996. Behav.Brain Res.73, 157.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A selective 5-HT1B/1D receptor antagonist. Selectivity was found to be similar for B (pki = 9.2-9.8 )and D (pki = 8.6-9.1) receptor types. GR 127935 works well in vivo and was shown to block (+)-MDMA-induced hyperactivity in rats. It alters release of serotonin in the brain, as well as reducing drug-seeking behaviour in cocaine addicted rats. In transformed rat C5 glioma cells, this inhibitor blocked 5HT with an IC50 = 97 pM.
Form
Off-white solid
CAS number
148642-42-6
Chemical formula
C₂₉H₃₁N₅O₃·HCl
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Rex, A. et al. 2008. Pharmacology, Biochemistry, and Behavior.88, 196. Przegalinski, E. et al. 2008. Pharmacol. Rep.60, 798. Bannai, M. et al. 2007. Psychopharmacol.93, 295. McCreary A. C. et al. 1999. J. Pharmacol. Exp. Ther.290, 965. Pauwels, P. J. et al. 1996. J. Neurochem.66, 65. Skingle, M. et al. 1996. Behav.Brain Res.73, 157.
