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14-820M Fms (Y969C) Protein, active, 250 µg

Active, N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end containing the mutation Y969C. For use in Kinase Assays.

14-820M
250 µg  Also available in 10 μg size (cat#14-820) and in bulk (cat# 14-820-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-820M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionFms (Y969C) Protein, active, 250 µg
      OverviewN-terminal His6-tagged, recombinant, human Fms, amino acids 538-end containing the mutation Y969C.
      References
      Product Information
      Presentation50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal His6-tagged, recombinant, human Fms, amino acids 538-end containing the mutation Y969C. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
      Gene Symbol
      • CSF1R
      • FIM2
      • CSF-1-R
      • C-FMS
      • CSFR
      • c-fms
      • CD115
      • FMS
      Protein TargetFms
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      Molecular Weight50.2kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-820) and in bulk (cat# 14-820-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-820M 04053252275593

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-820 Fms (Y969C) Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases