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324875 Eicosapentaenoic Acid - CAS 10417-94-4 - Calbiochem

Cell permeable. Shown to have a beneficial effect in cardiovascular diseases and inflammation. Inhibits 5-lipoxygenase and reduces thromboxane A₂ production and blood viscosity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: EPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3

Primary Target: 5-lipoxygenase
324875
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
10417-94-4C₂₀H₃₀O₂

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324875-25MG
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      		 Glass bottle 25 mg
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      Description
      OverviewCell permeable. Shown to have a beneficial effect in cardiovascular diseases and inflammation. Causes elevation of intracellular free Ca2+. Inhibits 5-lipoxygenase and reduces thromboxane A2 production and blood viscosity. Reported to induce apoptosis in pancreatic cancer cell lines and to inhibit liver metastasis.
      Catalogue Number324875
      Brand Family Calbiochem®
      SynonymsEPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3
      References
      ReferencesIwamoto, S., et al. 1998. Nutr. Cancer 31, 143.
      Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375.
      Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830.
      Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166.
      James, M.J., et al. 1993. J. Exp. Med. 178, 2261.
      chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19.
      Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.
      Product Information
      CAS number10417-94-4
      ATP CompetitiveN
      FormClear liquid
      Hill FormulaC₂₀H₃₀O₂
      Chemical formulaC₂₀H₃₀O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-lipoxygenase
      Purity≥99% by GC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSJX3820000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      324875-25MG 04055977215847

      Documentation

      Eicosapentaenoic Acid - CAS 10417-94-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      324875

      References

      Reference overview
      Iwamoto, S., et al. 1998. Nutr. Cancer 31, 143.
      Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375.
      Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830.
      Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166.
      James, M.J., et al. 1993. J. Exp. Med. 178, 2261.
      chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19.
      Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-May-2008 RFH
      SynonymsEPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3
      DescriptionFatty acid isolated from microscopic algae. Serves as a precursor for the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid by the extra double bond between C17 and C18. Has a beneficial effect in cardiovascular diseases and inflammation. Also acts as an antihyperlipoproteinenic agent. Causes elevations of intracellular free Ca2+. Inhibits 5-lipoxygenase and reduces thromboxane A2 production and blood viscosity.
      FormClear liquid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number10417-94-4
      RTECSJX3820000
      Chemical formulaC₂₀H₃₀O₂
      Structure formulaStructure formula
      Purity≥99% by GC
      SolubilityMethanol (1 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 3531
      ReferencesIwamoto, S., et al. 1998. Nutr. Cancer 31, 143.
      Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375.
      Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830.
      Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166.
      James, M.J., et al. 1993. J. Exp. Med. 178, 2261.
      chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19.
      Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.