324623 Sigma-AldrichEg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem
The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<Synonyms: 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
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Overview
Key Spec Table
CAS # | Empirical Formula |
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909250-29-9 | C₁₄H₁₁FN₂OS |
Pricing & Availability
Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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324623-5MG |
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Glass bottle | 5 mg |
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Description | |
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Overview | A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells. |
Catalogue Number | 324623 |
Brand Family | Calbiochem® |
Synonyms | 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione |
References | |
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References | Muller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157. Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024. Sarli, V., et al. 2005. ChemBioChem 6, 2005. |
Product Information | |
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CAS number | 909250-29-9 |
Form | White solid |
Hill Formula | C₁₄H₁₁FN₂OS |
Chemical formula | C₁₄H₁₁FN₂OS |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥99% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
324623-5MG | 04055977197389 |