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324623 Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem

The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione

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324623
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Overview

Key Spec Table

CAS #Empirical Formula
909250-29-9C₁₄H₁₁FN₂OS

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324623-5MG
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      Description
      OverviewA cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells.
      Catalogue Number324623
      Brand Family Calbiochem®
      Synonyms5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
      References
      ReferencesMuller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157.
      Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024.
      Sarli, V., et al. 2005. ChemBioChem 6, 2005.
      Product Information
      CAS number909250-29-9
      FormWhite solid
      Hill FormulaC₁₄H₁₁FN₂OS
      Chemical formulaC₁₄H₁₁FN₂OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      324623-5MG 04055977197389