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324630 EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem

The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor and adenosine deaminase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl

Primary Target: PDE 2
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324630
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Overview

Key Spec Table

CAS #Empirical Formula
51350-19-7C₁₄H₂₃N₅O · HCl

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324630-10MG
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      Description
      OverviewThe racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
      Catalogue Number324630
      Brand Family Calbiochem®
      Synonymserythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
      References
      ReferencesBurton, P., et al. 2010. Biochem. J. in press.
      Lorbar, M., et al. 1999. J. Mol. Cell. Cardiol. 31, 401.
      Verde, I., et al. 1999. Br. J. Pharmacol. 127, 65.
      Reynolds, A.J., et al. 1996. Brain Res. 798, 67.
      Mery, P.F., et al. 1995. Mol. Pharmacol. 48, 121.
      Podzuweit, T., et al. 1995. Cell. Signal. 7, 733.
      Bessodes, M., et al. 1982. Biochem. Pharmacol. 31, 879.
      Bouchard, P., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 1033.
      Product Information
      CAS number51350-19-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₂₃N₅O · HCl
      Chemical formulaC₁₄H₂₃N₅O · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetPDE 2
      Primary Target IC<sub>50</sub>0.8 and 2 µM against human and procine PDE II, respectively
      Primary Target K<sub>i</sub>4 nM against adenosine deaminase
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      324630-10MG 04055977196733