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211274 (E)-Capsaicin

(E)-Capsaicin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Primary Target: NF-κB
211274
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      404-86-4C₁₈H₂₇NO₃
      Description
      Overview

      This product has been discontinued.



      We are offering Capsaicin (Cat. No. 211275)as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






      An active constituent of cayenne pepper with excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced responses in rat PC12 cells. Exhibits anti-nociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
      Catalogue Number211274
      Brand Family Calbiochem®
      Synonyms[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
      References
      ReferencesSingh, S., et al. 1996. J. Immunol. 157, 4412.
      Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
      Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
      Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
      Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
      Pernow, B., et al. 1985. J. Immunol. 135, 8125.
      Product Information
      CAS number404-86-4
      FormWhite solid
      Hill FormulaC₁₈H₂₇NO₃
      Chemical formulaC₁₈H₂₇NO₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetNF-κB
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRA8530000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      211274 0

      Documentation

      (E)-Capsaicin Certificates of Analysis

      TitleLot Number
      211274

      References

      Reference overview
      Singh, S., et al. 1996. J. Immunol. 157, 4412.
      Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
      Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
      Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
      Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
      Pernow, B., et al. 1985. J. Immunol. 135, 8125.

      Citations

      Title
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      Synonyms[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
      DescriptionAn active constituent of cayenne pepper. Has excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced respones in rat pheochromocytoma cells. Exhibits antinociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
      FormWhite solid
      CAS number404-86-4
      RTECSRA8530000
      Chemical formulaC₁₈H₂₇NO₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityEthanol (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 1768
      ReferencesSingh, S., et al. 1996. J. Immunol. 157, 4412.
      Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
      Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
      Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
      Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
      Pernow, B., et al. 1985. J. Immunol. 135, 8125.
      Citation
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•