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251680 Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem

A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Ryanodine receptor
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251680
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
14663-23-1C₁₄H₉N₄O₅ · Na

Pricing & Availability

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251680-100MG
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      		 Plastic ampoule 100 mg
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      Description
      OverviewA cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor. Inhibits long-term depression and depotentiation of synaptic transmission. Has neuroprotective effects in cases of cerebral ischemia.
      Catalogue Number251680
      Brand Family Calbiochem®
      References
      ReferencesWei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
      O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
      Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
      Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
      Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
      Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
      Product Information
      CAS number14663-23-1
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₁₄H₉N₄O₅ · Na
      Chemical formulaC₁₄H₉N₄O₅ · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRyanodine receptor
      Purity≥ 95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMU3875000
      Safety Information
      R PhraseR: 20/21/22-45

      Harmful by inhalation, in contact with skin and if swallowed.
      May cause cancer.
      S PhraseS: 22-36/37/39-45

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      251680-100MG 07790788048983

      Documentation

      Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Dantrolene, Sodium Salt - CAS 14663-23-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      251680

      References

      Reference overview
      Wei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
      O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
      Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
      Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
      Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
      Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-June-2009 RFH
      DescriptionA skeletal muscle relaxant. Blocks intracellular calcium release from the sarcoplasmic reticulum during excitation-contraction coupling by binding to the ryanodine receptor. Blocks long-term depression and depotentiation.
      FormOrange solid
      CAS number14663-23-1
      RTECSMU3875000
      Chemical formulaC₁₄H₉N₄O₅ · Na
      Structure formulaStructure formula
      Purity≥ 95% by HPLC
      SolubilityAqueous alkaline solutions or DMSO (3 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 2816
      ReferencesWei, H., and Perry, D.C. 1996. J. Neurochem. 67, 2390.
      O’Mara, S.M., et al. 1995. Neuroscience 68, 621.
      Parness, J., and Palnitkar, S.S. 1995. J. Biol. Chem. 270, 18465.
      Zhang, H., et al. 1995. Am. J. Physiol. 269, H1874.
      Hotchkiss, R.S., and Karl, I.E. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.
      Song, S.K., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3039.