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204902 Complement C5a des-Arg, Human

Complement C5a des-Arg, Human, is a native, single chain glycopeptide (73 aa). Once produced, C5a is converted to C5a des-Arg upon removal of the C-terminal arginine by serum carboxypeptidase N.

Complement C5a des-Arg, Human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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204902
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Overview

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204902-30UG
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      		 Plastic ampoule 30 μg
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      Description
      OverviewNative, human des-Arg C5a complement component. Single chain glycopeptide composed of 73 amino acids. Once the C5a glycopeptide has been produced in human plasma or serum, it is rapidly converted to C5a des-Arg upon removal of the C-terminal arginine by the endogenous serum carboxypeptidase N. Unlike the C3a des-Arg peptide, C5a des-Arg retains significant levels of its biological activities. Thus, C5a des-Arg has been shown to exhibit inflammatory cell chemotaxis, smooth muscle contraction, and leukotriene release from guinea pig lung.
      Catalogue Number204902
      Brand Family Calbiochem®
      References
      ReferencesWebster, R.O., et al. 1980. Immunopharmacology 1, 201.
      McCarthy, K. and Henson, P.M. 1979. J. Immunol. 123, 2511.
      Product Information
      FormLiquid
      FormulationIn 120 mM NaCl, 10 mM HEPES, pH 7.2.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      SourcePrepared from plasma of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      204902-30UG 04055977219869

      Documentation

      Complement C5a des-Arg, Human SDS

      Title

      Safety Data Sheet (SDS) 

      Complement C5a des-Arg, Human Certificates of Analysis

      TitleLot Number
      204902

      References

      Reference overview
      Webster, R.O., et al. 1980. Immunopharmacology 1, 201.
      McCarthy, K. and Henson, P.M. 1979. J. Immunol. 123, 2511.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2010 RFH
      DescriptionNative, human des-Arg C5a complement component. Single chain glycopeptide composed of 73 amino acids. Once the C5a glycopeptide has been produced in human plasma or serum, it is rapidly converted to C5a des-Arg upon removal of the C-terminal arginine by the endogenous serum carboxypeptidase N. Unlike the C3a des-Arg peptide, C5a des-Arg retains significant levels of its biological activities. Thus, C5a-des-Arg has been shown to exhibit inflammatory cell chemotaxis, smooth muscle contraction, and leukotriene release reactions from guinea pig lung.
      FormLiquid
      FormulationIn 120 mM NaCl, 10 mM HEPES, pH 7.2.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from plasma of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥90% by SDS-PAGE
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesWebster, R.O., et al. 1980. Immunopharmacology 1, 201.
      McCarthy, K. and Henson, P.M. 1979. J. Immunol. 123, 2511.