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234200 Combretastatin A-4 - CAS 117048-59-6 - Calbiochem

A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine tubulin binding and interferes with tubulin polymerization as well as cellular microtubule assembly

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII, NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4

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234200
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
117048-59-6C₁₈H₂₀O₅

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234200-10MG
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      Description
      OverviewA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
      Catalogue Number234200
      Brand Family Calbiochem®
      SynonymsCombretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII, NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4
      References
      ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
      Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
      Pettit, G.R., et al. 1989. Experientia 45, 209.
      Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
      Product Information
      CAS number117048-59-6
      FormOff-white solid
      Hill FormulaC₁₈H₂₀O₅
      Chemical formulaC₁₈H₂₀O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      234200-10MG 04055977200126

      Documentation

      Combretastatin A-4 - CAS 117048-59-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Combretastatin A-4 - CAS 117048-59-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      234200

      References

      Reference overview
      Tron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
      Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
      Pettit, G.R., et al. 1989. Experientia 45, 209.
      Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2010 RFH
      SynonymsCombretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII, NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4
      DescriptionA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat. No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number117048-59-6
      Chemical formulaC₁₈H₂₀O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
      Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
      Pettit, G.R., et al. 1989. Experientia 45, 209.
      Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.