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220320 Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem

A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CS-1, CTM

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      Overview

      Key Spec Table

      CAS #Empirical Formula
      1403-36-7C₃₁H₃₀N₆O₆S₄
      Description
      OverviewA cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
      Catalogue Number220320
      Brand Family Calbiochem®
      SynonymsCS-1, CTM
      References
      ReferencesFujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
      Kung, A.L., et al. 2004. Cancer Cell 6, 33.
      Product Information
      CAS number1403-36-7
      FormOff-white solid
      Hill FormulaC₃₁H₃₀N₆O₆S₄
      Chemical formulaC₃₁H₃₀N₆O₆S₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Safety Information according to GHS
      RTECSFM3038000
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      220320 0