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238811 Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem

The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl

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Synonyms: 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol

Primary Target: Cdk9
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238811
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Overview

Key Spec Table

CAS #Empirical Formula
140651-18-9C₉H₁₀N₆O

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238811-5MG
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      Description
      OverviewA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
      Catalogue Number238811
      Brand Family Calbiochem®
      Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
      References
      ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.
      Product Information
      CAS number140651-18-9
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₉H₁₀N₆O
      Chemical formulaC₉H₁₀N₆O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCdk9
      Primary Target IC<sub>50</sub>350 nM, using Cdk9/T1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      238811-5MG 04055977216646