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235425 Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem

Fluorogenic caspase-3 substrate.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-DEVD-AMC

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235425
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Overview

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      235425-5MG
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          Description
          OverviewFluorogenic caspase-3 substrate. Cleavage of this substrate by caspase-3 shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 µM). Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.
          Catalogue Number235425
          Brand Family Calbiochem®
          SynonymsAc-DEVD-AMC
          References
          ReferencesHermission, M., et al. 2000. Oncogene 19, 2338.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Product Information
          CAS number169332-61-0
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₃₀H₃₇N₅O₁₃
          Chemical formulaC₃₀H₃₇N₅O₁₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetFluorogenic caspase-3 substrate
          Primary Target IC<sub>50</sub>Km = 9.7 ± 1.0 µM for cleavage of this substrate by caspase-3
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Emission max.
          Excitation max.
          Peptide SequenceAc-Asp-Glu-Val-Asp-AMC
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          235425-1MG 04055977217032
          235425-5MG 04055977217049

          Documentation

          Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Caspase-3 Substrate II, Fluorogenic - CAS 169332-61-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          235425

          References

          Reference overview
          Hermission, M., et al. 2000. Oncogene 19, 2338.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Nicholson, D.W., et al. 1995. Nature 376, 37.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2011 RFH
          SynonymsAc-DEVD-AMC
          DescriptionFluorogenic CPP32/Apopain substrate. Cleavage of this substrate by CPP32/Apopain shows Michaelis-Menten kinetics (Km = 9.7 ± 1.0 µM). Cleavage can be monitored by excitation at 380 nm and emission at 460 nm.
          FormOff-white solid
          CAS number169332-61-0
          Chemical formulaC₃₀H₃₇N₅O₁₃
          Peptide SequenceAc-Asp-Glu-Val-Asp-AMC
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mM)
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHermission, M., et al. 2000. Oncogene 19, 2338.
          Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
          Nicholson, D.W., et al. 1995. Nature 376, 37.