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505766 Casein Kinase II Inhibitor XII, TBBz - CAS 577779-57-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz

Primary Target: CK2
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      577779-57-8C₇H₂Br₄N₂
      Description
      OverviewA cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, Ki = 70 nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a′ subunits is significantly reduced (Ki = 510 and 400 nM, respectively). Reported to reduce viability and proliferation in HeLa, Jurkat, and HL-60 cells (at ˜25 µM). Also shown to disrupt the promoter activity of CYP24A1 and down-regulates its endogenous and 1, 25-Vitamin D3 (1,25-D3)-induced expression in PC3 cells. Synergistically enhances the anti-tumor effect of 1, 25-D3 in a PC3 xenograft murine model.
      Catalogue Number505766
      Brand Family Calbiochem®
      Synonyms4,5,6,7-Tetrabromobenzimidazole, CYP24A1 inhibitor, TBBz, CK2 Inhibitor, TBBz
      References
      ReferencesSzyszka, R. et al. 1995. Biochem. Biophys. Res. Comm. 208, 418.
      Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 306, 129.
      Zien, P. et al. 2003. Biochem. Biophys. Res. Comm. 312, 623.
      Zien, P. et al. 2005. Biochim. Biophy. Acta 1754, 271.
      Luo, W. et al. 2013. Cancer Res. 73, 2289.
      Product Information
      CAS number577779-57-8
      FormOff-white powder
      Hill FormulaC₇H₂Br₄N₂
      Chemical formulaC₇H₂Br₄N₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCK2
      Primary Target K<sub>i</sub>70 nM
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      505766 0