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212402 Carbacyclin

Stable, synthetic, carbacyclic analog of prostacyclin with similar spectrum of activity but is only 10% as potent.

Carbacyclin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Carbacyclic PGI₂

212402
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      69552-46-1C₂₁H₃₄O₄
      Description
      Overview

      This product has been discontinued.





      Stable, synthetic, carbacyclic analog of prostacyclin with similar spectrum of activity but is only 10% as potent. Activates adenylate cyclase via G-protein coupled PGI2 receptors. Mimics effects of naturally-occurring prostacyclin.
      Catalogue Number212402
      Brand Family Calbiochem®
      SynonymsCarbacyclic PGI₂
      References
      ReferencesIto, Y., et al. 1994. Atherosclerosis 110, 69.
      Sawai, T., et al. 1993. J. Biol. Chem. 268, 1995.
      Turner, J.T., et al. 1992. J. Pharmacol. Exp. Ther. 263, 708.
      Karim, S.M.M., et al. 1981. Prostaglandin Med. 6, 521.
      Aiken, J.W., et al. 1980. Prostaglandins 19, 629.
      Product Information
      CAS number69552-46-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₁H₃₄O₄
      Chemical formulaC₂₁H₃₄O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetActivates adenylate cyclase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      212402 0

      Documentation

      Carbacyclin Certificates of Analysis

      TitleLot Number
      212402

      References

      Reference overview
      Ito, Y., et al. 1994. Atherosclerosis 110, 69.
      Sawai, T., et al. 1993. J. Biol. Chem. 268, 1995.
      Turner, J.T., et al. 1992. J. Pharmacol. Exp. Ther. 263, 708.
      Karim, S.M.M., et al. 1981. Prostaglandin Med. 6, 521.
      Aiken, J.W., et al. 1980. Prostaglandins 19, 629.

      Brochure

      Title
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Bioactive Lipids Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsCarbacyclic PGI₂
      DescriptionStable, synthetic carbacyclic analog of prostacyclin that mimics the effects of naturally occurring prostacyclin, but is 10% as potent. Activates adenylate cyclase via G-protein coupled PGI2 receptors.
      FormWhite solid
      CAS number69552-46-1
      Chemical formulaC₂₁H₃₄O₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityEthanol, EtOAc, or Acetone
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesIto, Y., et al. 1994. Atherosclerosis 110, 69.
      Sawai, T., et al. 1993. J. Biol. Chem. 268, 1995.
      Turner, J.T., et al. 1992. J. Pharmacol. Exp. Ther. 263, 708.
      Karim, S.M.M., et al. 1981. Prostaglandin Med. 6, 521.
      Aiken, J.W., et al. 1980. Prostaglandins 19, 629.