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208733 Calpain Inhibitor Set - Calbiochem

The Calpain Inhibitor Set controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Calpain Inhibitor Set - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: calpain 1, calpain 2
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208733
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Overview

Replacement Information

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208733-1SET
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      Description
      OverviewContains 5 mg of ALLN (Cat. No. 208719), 25 mg of Calpain Inhibitor III (Cat. No. 208722), 5 mg of Calpeptin (Cat. No. 03-34-0051), 1 mg of EST (Cat. No. 330005), and 5 mg of PD 150606 (Cat. No. 513022).
      Catalogue Number208733
      Brand Family Calbiochem®
      References
      ReferencesJohnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
      Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
      Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
      Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
      Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
      Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
      Goll, D.E., et al. 1992. BioEssays 14, 549.
      Product Information
      FormSolid
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcalpain 1, calpain 2
      Primary Target K<sub>i</sub>8 nM
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      208733-1SET 04055977202755

      Documentation

      Calpain Inhibitor Set - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Calpain Inhibitor Set - Calbiochem Certificates of Analysis

      TitleLot Number
      208733

      References

      Reference overview
      Johnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
      Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
      Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
      Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
      Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
      Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
      Goll, D.E., et al. 1992. BioEssays 14, 549.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      DescriptionCalpains are a family of calcium-dependent thiol-proteases that act on a wide variety of cytoskeletal, membrane-associated, and regulatory proteins. There are two major isoforms: calpain I (µ-form) and calpain II (m-form), which differ in their calcium requirement for activation Calpains are composed of heterodimers of 80 kDa and a 30 kDa subunits. The 80 kDa unit has the catalytic site and is unique to each isozyme, whereas the 30 kDa unit is the regulatory subunit and is common to both µ- and m-isozymes.

      More recently, attention has been focused on the pathological significance of calcium accumulation in the central nervous system following cerebral ischemia and traumatic brain injury. Over-activation of NMDA, kainate, and AMPA receptors in the brain leads to sustained influx of Ca2+ through the voltage-gated calcium channels. Overexpression of calpains has been positively linked to both acute and chronic neurodegenerative processes including ischemia, trauma, and Alzheimer's disease. In Alzheimer's disease the ratio of active (76 kDa) to inactive (80 kDa) µ-calpain is reported to be much higher Calpain-dependent proteolysis is usually the late-stage common pathway towards cell death induced by excitotoxic compounds, hence, a selective inhibition of calpains to limit neuronal damage appears to be a viable therapeutic measure.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Toxicity Multiple Toxicity Values, refer to MSDS
      ReferencesJohnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
      Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
      Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
      Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
      Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
      Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
      Goll, D.E., et al. 1992. BioEssays 14, 549.