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SCC194 CT-2A Mouse Glioma Cell Line

CT-2A mouse glioma cell line is a valuable mouse model for therapeutic research on brain malignancies.

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SCC194
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC194
      DescriptionCT-2A Mouse Glioma Cell Line
      OverviewThe CT-2A cell line is derived from a sub-cutaneous, non-metastatic murine glioma (astrocytoma). The originating tumor was classified as poorly differentiated with high vascularity and malignancy (2). CT-2A cells are marked by high levels of complex gangliosides and low distribution of the anti-angiogenic ganglioside GM3, as well as deficiency in the tumor suppressor PTEN/TSC2, a characteristic present in up to 70% of human high-grade glioma cell lines (3,4). CT-2A tumors are wild-type for p53 and recapitulate several features of human high-grade glioma, including high mitotic index and cell density, nuclear polymorphism, hemorrhage, pseudopalisading necrosis, and microvascular proliferation (5,6).

      Source:
      CT-2A was generated from a malignant astrocytoma formed via implantation of the carcinogen 20-methylcholanthrene in the cerebrum of a C57BL/6J mouse (7). The tumor was maintained through serial intracranial transplants prior to cell line isolation.
      Alternate Names
      • CT2A
      Background InformationGlioblastomas are among the most aggressive forms of cancer, associated with low treatment efficacy and poor survival. Recurring glioblastomas are often resistant to first-line chemotherapies (1). There is much interest in studying drug-resistant forms of glioblastomas in the effort to develop effective therapies.

      References:
      1. Weller M, Cloughesy T, Perry JR, and Wick W (2013). Neuro Oncol 15(1): 4-27.
      2. Seyfried TN, el-Abbadi M, and Roy ML (1992). Mol Chem Neuropathol 17(2):147-167.
      3. Seyfried TN, Mukherjee P (2010). J Oncol 2010:961243 doi.10.1155/2010/961243.
      4. Cotterchio M, Seyfried TN (1994). J Lipid Res 35(1): 10-14.
      5. Binello E, Qadeer ZA, Kothari HP, Emdad L, Germano IM (2012). J Cancer 3: 166-174.
      6. Martinez-Murillo R, Martinez A (2007). Histol Histopathol 22(12): 1309-1326.
      7. Zimmerman HM and Arnold H. (1941). Cancer Res 1(12): 919-938.
      References
      Product Information
      Applications
      ApplicationCT-2A mouse glioma cell line is a valuable mouse model for therapeutic research on brain malignancies.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC194 04054839573729

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