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203292 Bisindolylmaleimide II - CAS 137592-45-1 - Calbiochem

A potent, cell permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC₅₀ = 13 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-[1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide

Primary Target: PKC
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      137592-45-1C₂₇H₂₆N₄O₂
      Description
      Overview

      This product has been discontinued.



      A potent, cell permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC50 = 13 nM). May inhibit protein kinase A at much higher concentrations (IC50 = 2 µM).
      Catalogue Number203292
      Brand Family Calbiochem®
      Synonyms2-[1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide
      References
      ReferencesToullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Product Information
      CAS number137592-45-1
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₂₇H₂₆N₄O₂
      Chemical formulaC₂₇H₂₆N₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>13 nM against protein kinase C
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203292 0

      Documentation

      Bisindolylmaleimide II - CAS 137592-45-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      203292

      References

      Reference overview
      Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      Synonyms2-[1-[2-(1-Methylpyrrolidino)ethyl]-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide
      DescriptionA potent, cell permeable, reversible, ATP-competitive and selective inhibitor of protein kinase C (IC50 = 13 nM). Also inhibits protein kinase A at much higher concentrations (IC50 = 2 µM).
      FormOrange solid
      CAS number137592-45-1
      Chemical formulaC₂₇H₂₆N₄O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesToullec, D., et al. 1991. J. Biol. Chem. 266, 15771.