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200499 Bexarotene - CAS 153559-49-0 - Calbiochem

A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner.

Bexarotene - CAS 153559-49-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

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200499
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
153559-49-0C₂₄H₂₈O₂

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200499-50MG
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      Description
      OverviewA retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.
      Catalogue Number200499
      Brand Family Calbiochem®
      Synonyms4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
      References
      ReferencesCramer, P.E., et al. 2012. Science Exp. 335, 1503.
      Product Information
      CAS number153559-49-0
      FormWhite to pale yellow powder
      Hill FormulaC₂₄H₂₈O₂
      Chemical formulaC₂₄H₂₈O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      200499-50MG 04055977221558

      Documentation

      Bexarotene - CAS 153559-49-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Bexarotene - CAS 153559-49-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      200499

      References

      Reference overview
      Cramer, P.E., et al. 2012. Science Exp. 335, 1503.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-December-2024 JSW
      Synonyms4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
      DescriptionA retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.
      FormWhite to pale yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number153559-49-0
      Chemical formulaC₂₄H₂₈O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; clear, colorless solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesCramer, P.E., et al. 2012. Science Exp. 335, 1503.