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189291 Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

Atorvastatin, Calcium Salt, CAS 134523-03-8, is a cell-permeable, highly potent, and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver

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Synonyms: (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,

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      Overview

      Key Spec Table

      CAS #Empirical Formula
      134523-03-8[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
      Description
      Overview

      This product has been discontinued.



      A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
      Catalogue Number189291
      Brand Family Calbiochem®
      Synonyms(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
      References
      ReferencesChen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
      Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
      Law, M.R., et al. 2003. BMJ 326, 1423.
      Youssef, S., et al. 2002. Nature 420, 78.
      Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
      Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
      Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
      Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
      Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.
      Product Information
      CAS number134523-03-8
      FormWhite powder
      Hill Formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
      Chemical formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAtorvastatin, Calcium Salt, CAS 134523-03-8, is a cell-permeable, highly potent, and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver).
      Biological Information
      Purity≥97% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      189291 0