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182541 Aromatase Inhibitor II, Letrozole - CAS 112809-51-5 - Calbiochem

The Aromatase Inhibitor II, Letrozole, also referenced under CAS 112809-51-5, controls the biological activity of Aromatase.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole

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182541
  
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      Overview

      Key Spec Table

      CAS #Empirical Formula
      112809-51-5C₁₇H₁₁N₅
      Description
      OverviewAn orally bioavailable non-steroidal triazole compound that acts as a potent and selective inhibitor of aromatase (IC50 = 140, 350 and 450 pM in Dex-treated fibroblasts, MCF-7Ca, and JEG-3 cells, respectively). Competitively, but reversibly binds to the heme iron of aromatase. Does not affect the synthesis of adrenal mineralocorticoid or glucocorticoids. Reported to be highly effective as an anti-estrogenic and anti-proliferative agent in estrogen-rich tumors. Also delays the fusing of the growth plates in adolescents and enhances the effectiveness of growth hormone. Shown to synergistically induce apoptosis and cause tumor regression when combined with IGF-1R inhibitors.
      Catalogue Number182541
      Brand Family Calbiochem®
      Synonyms4,4ʹ-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile, 1-(bis-(4-Cyanophenyl)methyl)-1,2,4-triazole
      References
      ReferencesHou, X., et al. 2011. Cancer Res. 71, 7597.
      Lisztwan, J., et al. 2008. Breast Cancer Res. 10, R56.
      Miller, W.R., et al. 2002. Cancer Invest. 20 (Suppl 2), 15.
      Long, B.J., et al. 1998. J. Steroid Biochem. Molec. Biol. 67, 293.
      Product Information
      CAS number112809-51-5
      FormWhite powder
      Hill FormulaC₁₇H₁₁N₅
      Chemical formulaC₁₇H₁₁N₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      182541 0