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07-868 Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody

This Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody is validated for use in WB for the detection of phospho-PKA Catalytic β subunit (Ser338).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: PRKACB, PKACB, MGC41879, MGC9320, DKFZp781I2452 UniProt Number: P22694
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07-868
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-868
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-PKA Catalytic β subunit (Ser338) Antibody
      References
      Product Information
      FormatAffinity Purified
      Presentation100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg2+ and Ca2+), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody is validated for use in WB for the detection of phospho-PKA Catalytic β subunit (Ser338).
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acid region encompassing the human, cow, and pig phospho-PKA Catalytic β (Ser338).
      HostRabbit
      SpecificityRecognizes phospho-PKA Catalytic β subunit (Ser338).
      IsotypeIgG
      Species Reactivity
      • Mouse
      Species Reactivity NotePredicted to cross-react with human based on sequence homology (100% homologous).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarycAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.
      Gene Symbol
      • PRKACB
      • PKACB
      • MGC41879
      • MGC9320
      • DKFZp781I2452
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P22694 # Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux.
      COFACTOR: Magnesium.
      SIZE: 351 amino acids; 40623 Da
      SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.
      SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).
      TISSUE SPECIFICITY: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoforms 3 and 4 are only epxressed in the brain.
      PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).
      SIMILARITY: SwissProt: P22694 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
      Molecular Weight~40 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C from date of shipment.
      Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-868 04053252513978

      Documentation

      Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-phospho-PKA Catalytic β subunit (Ser338) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-PKA Catalytic b subunit (Ser338) (Affinity purified Rabbit polyclonal IgG) - 2015531 2015531
      Anti-phospho-PKA Catalytic b subunit (Ser338) (Affinity purified Rabbit polyclonal IgG) - 2273802 2273802
      Anti-phospho-PKA Catalytic b subunit (Ser338) - DAM1487535 DAM1487535
      Anti-phospho-PKA Catalytic b subunit (Ser338) - DAM1588196 DAM1588196
      Anti-phospho-PKA Catalytic b subunit (Ser338) - NG1900703 NG1900703
      Anti-phospho-PKA Catalytic β subunit (Ser338) (Affinity purified Rabbit polyclonal IgG) 2983454
      Anti-phospho-PKA Catalytic β subunit (Ser338) - 2530513 2530513
      Anti-phospho-PKA Catalytic β subunit (Ser338) - 3448832 3448832
      Anti-phospho-PKA Catalytic β subunit (Ser338) - 3904625 3904625
      Anti-phospho-PKA Catalytic β subunit (Ser338) - 3914215 3914215
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