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ABE1331 Anti-Zinc finger protein Eos Antibody

This Anti-Zinc finger protein Eos antibody is validated for use in WB, IC for the detection of Zinc finger protein Eos.

Anti-Zinc finger protein Eos Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: IKZF4, KIAA1782, ZNFN1A4 UniProt Number: Q9H2S9
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ABE1331
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE1331
      DescriptionAnti-Zinc finger protein Eos Antibody
      Alternate Names
      • Zinc finger protein Eos
      • Ikaros family zinc finger protein 4
      Background InformationZinc finger protein Eos, also known as Zinc finger protein Eos, or Ikaros family zinc finger protein 4, and encoded by the gene name IKZF4/ KIAA1782/ ZNFN1A4, is a member of the Ikaros C2H2-type zinc-finger protein family. Zinc finger protein Eos is a DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. It is also a transcriptional repressor, which interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. Zinc finger protein Eos may be involved in the development of central and peripheral nervous systems. Zinc finger protein Eos interacts with other family members: IKZF1, IKZF2, IKZF3 AND IKZF5; as well as CTBP2, SPI1 and MITF. Zinc finger protein Eos is highly expressed in skeletal muscle, and with low levels of expression in heart, thymus, kidney, liver, and spleen. Zinc finger protein Eos is also expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. High level of expression has been detected in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Zinc finger protein Eos antibody is validated for use in WB, IC for the detection of Zinc finger protein Eos.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected Zinc finger protein Eos in 10 µg of human thymus tissue lysate.
      Immunocytochemistry Analysis: 1.0 µg/mL from a representative lot detected Zinc finger protein Eos in HepG2 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Zinc finger protein Eos near the C-terminus.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Mouse based on 100% sequence homology. Immunogen sequence is 93% homologous to Bovine.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IKZF4
      • KIAA1782
      • ZNFN1A4
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~60 kDa observed. This antibody is predicted to detect both isoforms of Zinc finger protein Eos (~64 & ~59 kDa) based on immunogen sequence. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Zinc finger protein Eos in 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABE1331 04055977117011