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ABC464 Anti-VAMP-3 Antibody

This Anti-VAMP-3 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of VAMP-3.

Anti-VAMP-3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: VAMP3, SYB3 UniProt Number: Q15836
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ABC464
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC464
      DescriptionAnti-VAMP-3 Antibody
      Alternate Names
      • Vesicle-associated membrane protein 3
      • VAMP-3
      • Cellubrevin
      • CEB
      • Synaptobrevin-3
      Background InformationVAMP-3 also known as cellubrevin is a vesicular transport protein and SNARE protein important in vesicle trafficking and exocytosis that helps regulate the release of critical components and processes such as blood clotting and inflammatory responses through the release of secretory granules and secretory vesicles. VAMP3 regulates the release of WPBs from endothelial cells. Weibel-Palade bodies (WPBs) are secretory organelles of endothelial cells that store the thrombogenic glycoprotein von Willebrand factor (vWF). Endothelial activation, for example by histamine and thrombin, triggers the Ca(2+)-dependent exocytosis of WPB that releases vWF into the vasculature and thereby initiates platelet capture and thrombus (blood clot) formation. VAMP3 is also critical to the release of proinflammatory compounds IL-6 and TNF-alpha.VAMP-3 is widely expressed in cells.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-VAMP-3 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of VAMP-3.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected VAMP-3 in 10 µg of Huvec and human brain tissue lysate.
      Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected VAMP-3 in PANC-1 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human VAMP-3 near the N-terminus.
      EpitopeNear N-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rat, Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • VAMP3
      • SYB3
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~13 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PANC-1 cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected VAMP-3 in 10 µg of PANC-1 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABC464 04055977051933