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AB15562-200UL Anti-Transient Receptor Potential Channel 7 Antibody

This Anti-Transient Receptor Potential Channel 7 Antibody is validated for use in IC, WB for the detection of Transient Receptor Potential Channel 7.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: TRPM7, TRP-PLIK, LTRPC7, LTrpC7, FLJ20117, CHAK, FLJ25718, CHAK1, EC 2.7.11.1 UniProt Number: Q96QT4
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AB15562-200UL
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RICC, WBRbPurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15562-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Transient Receptor Potential Channel 7 Antibody
      Alternate Names
      • TRPM7
      • LTRPC7
      • Channel-kinase 1
      References
      Product Information
      FormatPurified
      Control
      • Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The stock solution of the antigen can be made up using 100 μL of sterile deionized water. For negative control, preincubate 1 μg of peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationLyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA, and 0.05% sodium azide as a preservative. Reconstitute with 200 uL of sterile deionized water. Centrifuge antibody preparation before use (10,000 xg for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Transient Receptor Potential Channel 7 Antibody is validated for use in IC, WB for the detection of Transient Receptor Potential Channel 7.
      Key Applications
      • Immunocytochemistry
      • Western Blotting
      Application NotesWestern blot: 1:200-1:500 using ECL on mouse brain lysate and GH3 cell line (rat pituitary tumor) lysate.
      Immunocytochemistry: 1:200 using GH3 cell line (rat pituitary tumor).
      Dilutions should be made using a carrier protein such as BSA (1-3%).
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenPurified peptide from the C-terminus of human TRPM7 (Accession number Q96QT4).
      HostRabbit
      SpecificityRecognizes Transient Receptor Potential Channel 7 (TRPM7, LTRPC7, Channel-kinase 1).
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryTRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]
      Gene Symbol
      • TRPM7
      • TRP-PLIK
      • LTRPC7
      • LTrpC7
      • FLJ20117
      • CHAK
      • FLJ25718
      • CHAK1
      • EC 2.7.11.1
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96QT4 # Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
      COFACTOR: Binds 1 zinc ion per subunit (By similarity).
      SIZE: 1865 amino acids; 212697 Da
      SUBUNIT: Homodimer (By similarity). Forms heterodimers with TRPM6.
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Probable).
      PTM: Autophosphorylated (By similarity).
      DISEASE: SwissProt: Q96QT4 # Defects in TRPM7 influences susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 [MIM:105500]; also called amyotrophic lateral sclerosis- parkinsonism/dementia complex of Guam or Guam disease. Amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1 is a neurodengenerative disorder with unusually high incidence among the Chamorro people of the Western Pacific Islands of Guam. Both amyotrophic lateral sclerosis and parkinsonism-dementia are chronic, progressive, and uniformly fatal disorders in this population. Both diseases are known to occur in the same kindred, the same sibship, and even the same individual.
      SIMILARITY: SwissProt: Q96QT4 ## In the N-terminal section; belongs to the transient receptor family. LTrpC subfamily. & Contains 1 alpha-type protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB15562-200UL 04053252329203

      Documentation

      Anti-Transient Receptor Potential Channel 7 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Transient Receptor Potential Channel 7 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2330601 2330601
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2433284 2433284
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 - 4079382 4079382
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 -2639439 2639439
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 -2763867 2763867
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3113135
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY 2920898
      RABBIT ANTI-TRANSIENT RECEPTOR POTENTIAL CHANNEL 7 AFFINITY PURIFIED POLYCLONAL ANTIBODY -

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies