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AB2283 Anti-Tbr2 Antibody

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AB2283
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HIHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2283
      DescriptionAnti-Tbr2 Antibody
      Alternate Names
      • eomesodermin (Xenopus laevis) homolog
      • eomesodermin homolog (Xenopus laevis)
      • t box, brain, 2
      Background InformationTbr2 (a T-domain transcription factor) is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Trb2 has been shown to play a role in the development of the neocortex and functions in the differentiation pathway of radial glia to postmitotic projection neuron.
      References
      Product Information
      FormatAffinity Purified
      HS Code3002 15 90
      Control
      • Human Brain Tissue
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Tbr2 Antibody is validated for use in IH for the detection of Tbr2.
      Key Applications
      • Immunohistochemistry
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse Tbr2.
      EpitopeInternal Domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Tbr2.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteProven to react with human and mouse.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • eomes
      • TBR2
      • eomesodermin
      • tbr1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

      SUBCELLULAR LOCATION: Nucleus Probable.

      TISSUE SPECIFICTY: Expressed in CD8+ T-cells.

      DEVELOPMENTAL STAGE: Originally expressed in the trophoectoderm of the blastocyst and later in the extra-embryonic ectoderm of the early post-implantation embryo. In the embryo proper, expressed in the posterior part of the epiblast. During gastrulation, extends distally into the primitive streak and nascent mesoderm. Also expressed in the developing forebrain and the olfactory lobes. Expressed at E12.5 and E14.5 in the forebrain.

      INDUCTION: Up-regulated in CD8+ T-cells upon activation.

      DISRUPTION PHENOTYPE: Embryonic lethal due to peri-implantation defects. Mutant embryos arrest soon after implantation and fail to form organized embryonic or extraembryonic structures. Conditional mutants, with expression abrogated in the inner cell mass of embryos from early implantation stages onward, display gastrulation defects.

      SEQUENCE SIMLARITIES: Contains 1 T-box DNA-binding domain.
      Molecular WeightN/A
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry of human brain tissue.

      Immunohistochemistry Analysis: A 1:300 dilution of Anti-Tbr2 antibody from a previous lot detected Tbr2 in mouse and human brain tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB2283 04053252729454

      Documentation

      Anti-Tbr2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Tbr2 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Tbr2 - 2360624 2360624
      Anti-Tbr2 - 2464571 2464571
      Anti-Tbr2 - 1994916 1994916
      Anti-Tbr2 - 2042818 2042818
      Anti-Tbr2 - 2165867 2165867
      Anti-Tbr2 - 2281695 2281695
      Anti-Tbr2 - 3307333 3307333
      Anti-Tbr2 - 3474185 3474185
      Anti-Tbr2 - 3603681 3603681
      Anti-Tbr2 - 3786609 3786609

      References

      Reference overviewApplicationPub Med ID
      EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling.
      Chen, Q; Arai, D; Kawakami, K; Sawada, T; Jing, X; Miyajima, M; Hirai, S; Sakaguchi, K; Furushima, K
      PloS one  10  e0126942  2015

      Show Abstract
      25978062 25978062
      Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.
      Zhang, F; Xu, D; Yuan, L; Sun, Y; Xu, Z
      Nature communications  5  5815  2014

      Show Abstract
      25519973 25519973
      Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development.
      Tong, KK; Kwan, KM
      Molecular and cellular biology  33  1925-37  2013

      Show Abstract
      23459943 23459943
      Centrosome amplification causes microcephaly.
      Marthiens, Véronique, et al.
      Nat. Cell Biol., (2013)  2013

      Show Abstract
      23666084 23666084
      Process-based expansion and neural differentiation of human pluripotent stem cells for transplantation and disease modeling.
      Stover, AE; Brick, DJ; Nethercott, HE; Banuelos, MG; Sun, L; O'Dowd, DK; Schwartz, PH
      Journal of neuroscience research  91  1247-62  2013

      Show Abstract
      Immunocytochemistry23893392 23893392
      Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development.
      Saurat, N; Andersson, T; Vasistha, NA; Molnár, Z; Livesey, FJ
      Neural development  8  14  2013

      Show Abstract
      Immunohistochemistry23895693 23895693
      A human stem cell model of early Alzheimer's disease pathology in Down syndrome.
      Shi, Yichen, et al.
      Sci Transl Med, 4: 124ra29 (2012)  2012

      Show Abstract
      22344463 22344463
      Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development.
      Cheng, Aiwu, et al.
      J. Neurosci., 30: 10752-62 (2010)  2010

      Show Abstract
      20702706 20702706

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