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MABF1966-100UG Anti-TSLP Receptor Antibody, clone 22H9

Anti-TSLP Receptor, clone 22H9, Cat. No. MABF1966, is a rat monoclonal antibody that detects TSLP receptor and has been tested for use in Flow Cytometry.

Anti-TSLP Receptor Antibody, clone 22H9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: Crlf2, rlm2, Tpte2, Tslpr UniProt Number: Q8CII9
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MABF1966-100UG
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF1966-100UG
      DescriptionAnti-TSLP Receptor Antibody, clone 22H9
      Alternate Names
      • Cytokine receptor-like factor 2
      • Cytokine receptor-like molecule 2
      • CRLM-2
      • Thymic stromal lymphopoietin protein receptor
      • Type I cytokine receptor delta 1
      Background InformationCytokine receptor-like factor 2 (UniProt: Q8CII9; also known as Cytokine receptor-like molecule 2, CRLM-2, Thymic stromal lymphopoietin protein receptor, TSLP receptor, Type I cytokine receptor delta 1) is encoded by the Crlf2 (also known as rlm2, Tpte2, Tslpr) gene (Gene ID: 57914) in murine species. TSLP receptor is a single-pass type I membrane protein that serves as a receptor for thymic stromal lymphopoietin. It is expressed in liver, lung, testis, heart, brain, spleen, thymus, and bone marrow. Higher expression levels are observed in progenitors and myeloid cells. Its levels can be up-regulated in the myeloid 32D cell line by granulocyte colony-stimulating factor. TSLP receptor forms a functional complex with TSLP and IL7R, which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. It has also been implicated in the development of the hematopoietic system. It is synthesized with a signal peptide (aa 1-19), which is subsequently cleaved off to generate the mature form. The mature form contains an extracellular domain (aa 20-232), a transmembrane domain (aa 233-253), and a cytoplasmic domain (aa 254-359). It contains WSXWS motif (aa 201-205), which is essential for proper protein folding and efficient intracellular transport and cell-surface binding. It also has a Box 1 motif (aa 262-270) that is required for JAK interaction and activation.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-TSLP Receptor, clone 22H9, Cat. No. MABF1966, is a rat monoclonal antibody that detects TSLP receptor and has been tested for use in Flow Cytometry.
      Key Applications
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: A representative lot detected TSLP receptor in Flow Cytometry applications (Bell, B.D., et. al. (2013). Nat Immunol. 14(4):364-71; Isaksen, D.E., et. al. (2002). J Immunol. 168(7):3288-94; Iseki, M., et. al. (2012). Int Immunol. 24(3):183-95; Kashiwagi, M., et. al. (2017). Nat Immunol. 18(3):334-343).
      Biological Information
      ImmunogenHis-tagged murine recombinant TSLP Receptor Protein.
      Epitopeextracellular domain
      Clone22H9
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityClone 22H9 is a rat monoclonal antibody that detects Thymic stromal lymphopoietin protein receptor (TSLPR) in murine species. It targets an epitope with in the extracellular domain.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Crlf2
      • rlm2
      • Tpte2
      • Tslpr
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight37.76 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in bone marrow cells from C57BL/6 Mouse.

      Flow Cytometry Analysis: 1 µg of this antibody detected TSLP receptor in one million bone marrow cells from C57BL/6 Mouse.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF1966-100UG 04054839577239