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AB8230 Anti-Syndecan-1 Antibody

Anti-Syndecan-1 Antibody is an antibody against Syndecan-1 for use in WB.

Anti-Syndecan-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: ECM Proteins Gene Symbol: CD138 , SDC, SYND1 , syndecan , OTTHUMP00000115942 UniProt Number: P18827
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AB8230
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB8230
      DescriptionAnti-Syndecan-1 Antibody
      Alternate Names
      • CD138 antigen
      • heparan sulfate proteoglycan fibroblast growth factor
        receptor
      • syndecan 1
      • syndecan proteoglycan 1
      Background InformationSyndecan-1, also known as CD138, is a transmembrane (Type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization. Bearing properties of both heparan sulfate and chondroitin sulfate, Syndecan-1 functions as a cell surface proteoglycan membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types.
      References
      Product Information
      FormatSerum
      Control
      • Mouse liver lysate
      PresentationRabbit serum containing 0.05% NaN3.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Syndecan-1 Antibody is an antibody against Syndecan-1 for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenHis-tagged, full-length human recombinant Syndecan-1 protein.
      HostRabbit
      SpecificityCat. No. AB8230 recognizes mouse Syndecan-1.
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteMouse. Predicted to cross react with human, based on 100% sequence homology. Reactivity with other species has not been tested.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq]
      Gene Symbol
      • CD138
      • SDC
      • SYND1
      • syndecan
      • OTTHUMP00000115942
      UniProt Number
      UniProt SummaryFUNCTION:Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
      SUBUNIT STRUCTURE: Interacts with CDCP1.
      SUBCELLUAR LOCATION: Membrane; Single-pass type I membrane protein.
      SEQUENCE SIMILARITIES: Belongs to the syndecan proteoglycan family.
      Molecular WeightThe expected molecular weight of monomeric Syndecan-1 is ~32 kDa; however, the core protein often migrates as an SDS-stable dimer with an approximate M.W. of 77 kDa. Additionally, a high M.W. form of the protein may often be seen between 500-1000 kDa, likely the mature form of Syndecan-1, with all of its heparan and chondroitin sulfate additions. In whole tissues, this mature form often binds tightly to ECM molecules and may require solublization by urea extraction for additional SDS-PAGE analysis (Wilsie, 2006). Triton X-100 or similar mild detergents are sufficient to release the immature precursor forms of Syndecan-1.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated on a representative lot by Western blot on mouse liver lysate using 1:1000 dilution of Anti-Syndecan-1.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 1 year from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB8230 04053252743429

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies