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AB5358-200UL Anti-Sodium Channel NaB2 Antibody

Anti-Sodium Channel NaB2 Antibody detects level of Sodium Channel NaB2 & has been published & validated for use in IH & WB.

Anti-Sodium Channel NaB2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Ion Channels & Transporters Gene Symbol: SCN2B, ORFNames=UNQ326/PRO386 UniProt Number: O60939
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AB5358-200UL
200 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHC, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5358-200UL
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Sodium Channel NaB2 Antibody
      Alternate Names
      • B2 Subunit of Voltage-Gated Na+ Channel
      • SCN2B
      References
      Product Information
      FormatAffinity Purified
      Control
      • CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen (lyophilized powder). For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
      PresentationAffinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA, and 0.05 % sodium azide. Reconstitute with 200 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min).
      Quality LevelMQ100
      Applications
      ApplicationAnti-Sodium Channel NaB2 Antibody detects level of Sodium Channel NaB2 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blotting: 1:200 on rat brain membranes.

      Immunohistochemistry on rat brain sections.

      Dilutions should be made using a carrier protein such as BSA (1-3%).

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenHighly purified peptide corresponding to residues 197-215 of rat beta2 subunit of voltage-gated Na+ channels (Isom et al. 1995). Accession P54900. It is expected to work on human because the immunogen sequence is highly conserved (17/19 residues). Reactivity with other species has not yet been tested.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Nab2. The epitope specific for Nab2 is not present in any other known proteins.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SCN2B
      • ORFNames=UNQ326/PRO386
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O60939 # Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
      SIZE: 215 amino acids; 24326 Da
      SUBUNIT: The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Brain specific.
      SIMILARITY: SwissProt: O60939 ## Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C for up to 6 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5358-200UL 04053252511387

      Documentation

      Anti-Sodium Channel NaB2 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Sodium Channel NaB2 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-Nab2 (b2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2003671 2003671
      RABBIT ANTI-Nab2 (b2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 2197190 2197190
      RABBIT ANTI-Naβ2 (β2 Subunit Of Voltage-Gated Sodium Channel) - 4020595 4020595
      RABBIT ANTI-Naβ2 (β2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 3026852
      RABBIT ANTI-Naβ2 (β2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY 3038008

      Data Sheet

      Title
      RABBIT ANTI-Na2 (2 Subunit Of Voltage-Gated Sodium Channel) AFFINITY PURIFIED, POLYCLONAL ANTIBODY