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MABS1147 Anti-SH2D1A Antibody, clone SuGr-20 18A9

Anti-SH2D1A Antibody, clone SuGr-20 18A9 is an antibody against SH2D1A for use in Western Blotting.

Anti-SH2D1A Antibody, clone SuGr-20 18A9 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Immunological Signaling Gene Symbol: SH2D1A, DSHP, SAP, XLP, XLP1, XLPD UniProt Number: O60880
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MABS1147
100 μg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1147
      DescriptionAnti-SH2D1A Antibody, clone SuGr-20 18A9
      Alternate Names
      • SH2 domain-containing protein 1A
      • Duncan disease SH2-protein
      • Signaling lymphocytic activation molecule-associated protein
      • SLAM-associated protein
      • T-cell signal transduction molecule SAP
      Background InformationSH2 domain-containing protein 1A (UniProt O60880; also known as Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP) is encoded by the SH2D1A (also known as DSHP, SAP, XLP, XLP1, XLPD) gene (Gene ID 4068) in human. SAP/SH2D1A is a 628-amino acid (isoform A) adaptor protein expressed in T cells, natural killer (NK) cells, NK-T cells, and some B cells. SAP/SH2D1A is made up almost exclusively of a Src homology 2 (SH2) domain (a.a. 6-104) and plays an important role in multiple immune cell functions, including T helper 2 (TH2) cytokine production, T cell-dependent antibody production, follicular T helper (TFH) cell differentiation, NK-T cell development, CD8+ T cell- and NK cell-mediated cytotoxicity. SAP couples signaling lymphocytic activation molecule (SLAM) family receptors to tyrosine phosphorylation signals through its interaction with the SH3 domain of Src family protein tyrosine kinase Fyn. In addition, SAP can prevent SH2 domain-containing negative regulators, such as phosphatases SHIP-1 and SHP-1, from inactivating SLAM-related receptors by blocking their interaction with the receptors. Evidence also shows that SAP/SH2D1A regulates T cell-dependent antibody production and TFH cell differentiation independent of Fyn. SAP/SH2D1A gene is mutated and inactivated in X-linked lymphoproliferative disease, a rare human immunodeficiency characterized by an uncontrolled immune response to Epstein-Barr virus infection.
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-SH2D1A Antibody, clone SuGr-20 18A9 is an antibody against SH2D1A for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant full-length human SH2D1A.
      CloneSuGr-20 18A9
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone SuGr-20 18A9 recognizes recombinant full-length human SH2D1A spliced isoform A (UniProt O60880-1) by Western blotting. Reactivity toward spliced isoforms B to F (UniProt O60880-2 to O60880-6) has not been determined.
      IsotypeIgG2bκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SH2D1A
      • DSHP
      • SAP
      • XLP
      • XLP1
      • XLPD
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~14 kDa observed. 14.19 kDa calculated.
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting of recombinant human SH2D1A.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected 0.1 µg of recombinant human SH2D1A.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Global Trade Item Number
      Catalogue Number GTIN
      MABS1147 04055977335323