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07-2123 Anti-Ras-related protein Ral-A Antibody

Anti-Ras-related protein Ral-A Antibody is a highly specific rabbit polyclonal antibody, that targets Ral & has been tested in western blotting & ICC.

Anti-Ras-related protein Ral-A Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: RAL, RALA UniProt Number: P11233
07-2123
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-2123
      DescriptionAnti-Ras-related protein Ral-A Antibody
      Alternate Names
      • RAS-like protein A
      • Ras family small GTP binding protein RALA
      • Ras-related protein Ral-A
      • ras related v-ral simian leukemia viral oncogene homolog A
      • v-ral simian leukemia viral oncogene homolog A (ras related)
      Background InformationRalA and RalB are Ras-family small monomeric GTPases that can be activated through a Ras-dependent mechanism. The two are highly homologous (89%). Ral proteins are proximal effectors of oncogenic Ras and their activity is needed to support tumorigenesis in certain cancers. Mutants of Ras that are defective in activating all known Ras effectors except Ral GEF are still able to induce invasive phenotypes in transfected cells, suggesting a role for Ral in these processes. RalA is required for anchorage-independent proliferation and tumorigeneisis by driving exocyst assembly and polarized exocytosis in epithelial cells.
      References
      Product Information
      FormatAffinity Purified
      Control
      • HeLa cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Applications
      ApplicationAnti-Ras-related protein Ral-A Antibody is a highly specific rabbit polyclonal antibody, that targets Ral & has been tested in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a previous lot detected Ras-related protein Ral-A in A431 cells.
      Biological Information
      ImmunogenLinear peptide corresponding to human Ras-related protein Ral-A.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Ras-related protein Ral-A.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq].
      Gene Symbol
      • RAL
      • RALA
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummarySUBUNIT STRUCTURE; Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1.

      SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

      SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Ras family.
      Molecular Weight~ 25 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in HeLa cell lysate.

      Western Blot Analysis: 0.25 µg/mL of this antibody detected Ras-related protein Ral-A on 10 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-2123 04053252650383

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies