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AB15454 Anti-Proteolipid Protein Antibody

Detect Proteolipid Protein using this Anti-Proteolipid Protein Antibody validated for use in IC, IH.

Anti-Proteolipid Protein Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers, Neurodegenerative Diseases Gene Symbol: PLP1, lipophilin, MMPL, PLP/DM20, PLP, PMD, SPG2, Lipophilin UniProt Number: P60201
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AB15454
500 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MICC, IHCChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15454
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Proteolipid Protein Antibody
      Alternate Names
      • PLP
      References
      Product Information
      FormatAffinity Purified
      PresentationLiquid in PBS, pH 7.2 with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Proteolipid Protein using this Anti-Proteolipid Protein Antibody validated for use in IC, IH.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:100-1:200 using 2% paraformaldehyde fixed tissue.
      Immunocytochemistry: 1:100-1:200 using 2% paraformaldehyde fixed cells.
      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to human/mouse PLP protein.
      HostChicken
      SpecificityPLP [Proteolipid Protein]
      Species Reactivity
      • Mouse
      Species Reactivity NoteOther species have not yet been tested. It is expected that the antibody will also react with human due to immunogen sequence similarity.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. The encoded protein functions in myelination. This protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations associated with this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Two transcript variants encoding distinct isoforms have been identified for this gene.
      Gene Symbol
      • PLP1
      • lipophilin
      • MMPL
      • PLP/DM20
      • PLP
      • PMD
      • SPG2
      • Lipophilin
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P60201 # This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
      SIZE: 277 amino acids; 30077 Da
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      DISEASE: SwissProt: P60201 # Defects in PLP1 are the cause of Pelizaeus-Merzbacher disease (PMD) [MIM:312080]. PMD is an X-linked neurologic disorder of myelin metabolism. It is characterized by early impairment of motor development (during the first three months of life) and, later, by the development of abnormal movements and progressive spastic paraplegia. & Defects in PLP1 are the cause of spastic paraplegia type 2 (SPG2) [MIM:312920]. SPG2 is a form of X-linked hereditary spastic paraplegia (HSP). HSP is a group of inherited degenerative spinal cord disorders characterized by a slow, gradual, progressive weakness and spasticity of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Additional features include nystagmus, dysarthria and mental retardation, that are found in the complicated form of spastic paraplegia.
      SIMILARITY: SwissProt: P60201 ## Belongs to the myelin proteolipid protein family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size500 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB15454 04053252624254

      Documentation

      Anti-Proteolipid Protein Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Proteolipid Protein Antibody Certificates of Analysis

      TitleLot Number
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) POLYCLONAL ANTIBODY - 2148894 2148894
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) - 3497285 3497285
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) - 3731610 3731610
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) - 4013900 4013900
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) -2582843 2582843
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) -2608170 2608170
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) -2676220 2676220
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) -2783114 2783114
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) POLYCLONAL ANTIBODY - 2287766 2287766
      CHICKEN ANTI-PROTEOLIPID PROTEIN (PLP) POLYCLONAL ANTIBODY - 2365790 2365790

      Newsletters / Publications

      Title
      Cellutions - The newsletter for Cell Biology Researchers Volume 3: 2011

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies