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MABN746 Anti-Prestin, clone 3A2.2

Anti-Prestin Antibody, clone 3A2.2 is an antibody against Prestin for use in Western Blotting.

Anti-Prestin, clone 3A2.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: SLC26A5, PRES UniProt Number: P58743
MABN746
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN746
      DescriptionAnti-Prestin, clone 3A2.2
      Alternate Names
      • Prestin
      • Solute carrier family 26 member 5
      Background InformationPrestin is a motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter that can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate to translocate anions toward or away from the extracellular plasma membrane surface. As a consequence, this translocation triggers conformational changes in Prestin that ultimately alter its surface area in the plane of the plasma membrane. Prestin acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space and in that process it helps to modulate the electro-physical signals necessary for hearing. Prestin is expressed in outer hair cells and localized to the cell membrane. Mutations in Prestin can lead to deafness.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-Prestin Antibody, clone 3A2.2 is an antibody against Prestin for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenLinear peptide corresponding to human Prestin.
      Clone3A2.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC26A5
      • PRES
      UniProt Number
      Molecular Weight~77 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse ear tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Prestin in 10 µg of mouse ear tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN746 04055977136340