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AB9602 Anti-Plexin-A1 Antibody

This Anti-Plexin-A1 Antibody is validated for use in WB for the detection of Plexin-A1.

Anti-Plexin-A1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Growth Cones & Axon Guidance Gene Symbol: PLXNA1, NOV, PLXN1, PLEXIN-A1, NOVP UniProt Number: Q9UIW2
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AB9602
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9602
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Plexin-A1 Antibody
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS containing 50% glycerol, 1 mg/mL BSA and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Plexin-A1 Antibody is validated for use in WB for the detection of Plexin-A1.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1,000 on neonatal rat brain and COS-7 cells transfected with mouse Plexin-A1. The antibody reacts with the ~220 kDa protein. The suggested antibody diluent is PBS containing 5% non-fat milk and 0.04% Tween 20. Other bands may be present depending on the concentration of antibody and sample used.
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the semaphorin domain of human plexin-A1.
      HostRabbit
      SpecificityPlexin-A1. The immunogen sequence has low homology with other plexin family members.
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PLXNA1
      • NOV
      • PLXN1
      • PLEXIN-A1
      • NOVP
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9UIW2 # Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).
      SIZE: 1896 amino acids; 211087 Da
      SUBUNIT: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
      TISSUE SPECIFICITY: Detected in fetal brain, lung, liver and kidney.
      SIMILARITY: SwissProt: Q9UIW2 ## Belongs to the plexin family. & Contains 4 IPT/TIG domains. & Contains 1 Sema domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB9602 04053252285912